“Prestigious” is an interesting word and I believe is somewhat subjective based on who you’re talking to. While the general public might think a Delta or United pilot out ranks a FedEx “freight dog”, the truth is those guys get paid VERY well, are some of the toughest jobs to get and very well respected by their peers.
As for their schedules they can vary dramatically depending on the aircraft they fly and their seniority. One of the neat things at UPS is all their pilots are paid based on seniority vs what aircraft they fly. What that does is allow someone very senior to get paid at the top of the pay-scale but fly the aircraft and the route they want. Definitely not a bad gig.